Space is a new frontier in biology for two reasons: firstly we can use the lack of gravity for experiments that outperform terrestrial settings, and secondly because we need a whole set of new technology and know-how to tackle the space environment for human life. This project will produce a shared, peer‑reviewed technical baseline for MoonDAO’s future biological mission design and funding. The paper will collect and organize research, examples, and companies into a reliable review paper to help guide the whole sector. This helps MoonDAO and others understand the landscape of space bio, helps direct research, funding, and policy. The work will be coordinated by Expanse Bio, a new hub accelerating space biotech. The team of scientists leading this project have multiple experiences publishing high impact studies.